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SMTP server error: 0x800ccc14 with Classic ASP/IIS7

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In our live environment, we run 4 Windows Server 2008 servers with IIS7 using Classic ASP. Randomly once a week, all of our forms that utilize an email response, break upon submission and show the following error:

"The message could not be sent to the SMTP server. The transport error code was 0x800ccc14. The server response was not available"

Things to note:
-nothing shows up in the event logs
-we used wireshark, the SMTP packets don't get created/leave the server
-to fix the issue, we have to reboot the server (very annoying to reboot 1 server every week, its never the same server)

So my assumption is, its an IIS issue. Anyone have an ideas on how to fix or troubleshoot this issue?


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